Colorectal & Haematological

Lead Registry Areas - Colorectal and Haematological Cancers

The two site groupings for which NYCRIS has the lead for nationally based analyses are colorectal and haematological cancers. For both of these groupings, NYCRIS has benefited for some time from the local interest and enthusiasm of clinicians and pathologists interested in exploiting the potential of population-based comprehensive datasets. NYCRIS has also had a ‘headstart’ with national work in colorectal cancers as a result of receiving (together with the University of Leeds) funding for research projects from, initially, the PELICAN Foundation and then from Cancer Research UK. It is likely that from 2009/10 and subsequently, further funding will be available from the NCIN for lead area activity. Formal National Site Specific Clinical Reference Groups (SSCRG) have been created. NCIN also hosts all lead area pages, including Colorectal & Haematological cancers

Colorectal Cancer

In colorectal cancer, a national dataset has been created for cancers diagnosed 1995-2004 and this has been linked to HES, extensively cleaned and used for analyses of surgical procedures in rectal cancer, post-operative mortality, workload and consultant specialisation, liver resection for metastatic disease and evaluation of the PELICAN training programme. This work has been widely cited as a model for future outputs from lead registries and led to the award of a prestigious six-year Cancer Research UK- Bobby Moore Career Development Fellowship to Dr Morris. Further analyses are planned after enhancements to the dataset to evaluate the Colorectal Cancer Screening Programme, to investigate the effect of ethnicity on incidence and survival of colorectal cancer, to look at outcomes of patients with defined genetic alterations and to conduct long-term follow-up of clinical trial populations. Some of these analyses have been presented as posters.

The latest figures for Colorectal Cancer survival by stage (23 Jun 2009) are the first to be based on national statistics and have been published by the National Cancer Intelligence Network (NCIN) and the Northern and Yorkshire Cancer Registry and Information Service (NYCRIS).

Researchers at NYCRIS (led by Dr Eva Morris) have just published (11 April 2011) an article in Gut (BMJ journal), which shows the variation in survival between hospital trusts, within 30 days of colorectal cancer surgery - read more.... Direct link to NCIN Summary datasheet and eAtlas presentation. Read abstract/full article in Gut

Haematological Cancer

This work is coordinated by a local lead researcher, Dr Steven Oliver (affiliated with the Leukaemia Research Fund Epidemiology and Genetics Unit at York University), in collaboration with several clincical leads for haematology. An information analyst (funded by the NCIN, shared with colorectal cancer), works with a national haematological cancer dataset, which comprises, in the first instance, registry data linked to HES. Some of the preliminary analyses have been presented as posters.

The Oxford Cancer Intelligence Unit (OCIU) has recently produced a report on haematological malignancies which can be accessed here (18 Nov 2010). Haematological cancers have been described in the diagnostic groups of most interest to clinicians, including acute and chronic leukaemia, Hodgkin’s and non-Hodgkin’s lymphoma and multiple myeloma. The report also presents information on myelodysplasia and myeloproliferative disorders. The report covers the three cancer networks: Thames Valley (TV), Central South Coast (CSC) and the part of East Midlands Cancer Network that covers Leicestershire, Northamptonshire and Rutland (LNR). NYCRIS will be producing an equivalent document for all English Cancer Networks during 2011 as part of its work programme as lead registry for haematological malignancies.

An analysis of the latest ONS mortality statistics for England Wales (2001-09) has been carried out (April 2011) in order to examine the patterns of place of death seen for haematological cancers. This forms the basis for a NCIN data briefing which you can access here and an eAtlas that allows you to explore the variation in patterns seen by cancer network and the different forms of haematological cancer.